Medizinische Klinik und Poliklinik II
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Mikrobiom im Gastrointestinaltrakt

Mikrobiom im Gastrointestinaltrakt

AG Schulz

The microbial contribution to pre-cancerous changes of the stomach

The team focuses on the bacterial communities and their contribution to the onset of diesease. The emphasis is the upper gastrointestinal tract regarding the influence of the hosts’ microbiota on the infection with the obligatory pathogen Helicobacter pylori. The acceleration of pre-cancerous changes in the stomach by bacteria could be shown in animal models; we could add indications for humans from in vivo data. Additionally, the influence of the virome to H. pylori infections is investigated.

The mucosal milieu of the gastrointestinal tract

The characterization of the mucosal milieu for different degrees of severity of H. pylori induced gastritis aims to delineate the interaction between the pathogen, the local microbiota, and the host, and thereby identifying possibilities of interventions to stop the advancement of malignal transformations. One of the main focuses lies on the bacterial metabolites as well as the interaction between the bacteria and the immune cells of the host.

Genome-based predictions of antibiotic resistance in H. pylori

Within the scope of the Bavarian Research Network, we are building a database that includes the genotypic as well the phenotypic data about H. pylori, including informations regarding the site of infection (e.g. inflammatory parameter, microbiome signatures, etc.). The collected data will be used to develop an algorithm to predict antibiotic resistances based on sequencing data, enabling to chose the best fitting antibiotic therapy for individual H. pylori infected patients.

(With courtesy of the Bavarian Research Network)

New diagnostic methods to identify H. pylori infections

In translational/clinical project we focus on the diagnostic investigation of pre-cancerous gastric lesions in asymptomatic patients to best stratify those individuals who are under risk to go into endoscopic surveillance. New methods and technology is tested during the endoscopic procedure to get results in an optimized and fast procedure.